Man sitting by window looking sad, representing depression

DSM-5 · F32–F33

Depression

Major Depressive Disorder is a leading cause of disability worldwide, affecting mood, energy, and the ability to experience pleasure.

DSM-5 Clinical Definition

"Depressed mood or loss of interest or pleasure in nearly all activities, present for most of the day, nearly every day, for at least two weeks."

Depression (Major Depressive Disorder) is a serious medical condition that affects how a person feels, thinks, and handles daily activities. It is not simply sadness or a sign of weakness — it is a complex brain disorder involving changes in neurotransmitter systems, stress hormones, and neural circuitry. Depression affects over 280 million people globally and is the leading cause of disability worldwide. With proper treatment, the vast majority of people with depression experience significant improvement.

Ready to get help?

Board-certified PMHNP-BC Zoe Karpee provides evidence-based psychiatric care in East Flat Rock, NC and statewide via telehealth.

Book an Appointment (828) 316-5548

New patients welcome · Telehealth statewide

Signs & Symptoms

Symptoms vary by individual. A clinical evaluation is required for diagnosis.

Persistent low mood

Feeling sad, empty, hopeless, or tearful most of the day, nearly every day.

Loss of interest

Markedly diminished interest or pleasure in activities once enjoyed, including hobbies, socializing, and sex.

Fatigue and low energy

Persistent tiredness, physical slowing, and lack of motivation even after adequate rest.

Cognitive changes

Difficulty concentrating, making decisions, or remembering things; slowed thinking.

Sleep changes

Insomnia (difficulty falling or staying asleep) or hypersomnia (sleeping too much).

Thoughts of death

Recurrent thoughts of death or suicide, or a suicide attempt. Seek emergency care immediately if present.

Evidence-Based Treatment

At Wellness Behavioral Health and Healing PLLC, treatment plans are individualized and grounded in the latest psychiatric evidence. Options may include:

  • Antidepressant medications (SSRIs, SNRIs, bupropion, mirtazapine)
  • Augmentation strategies for treatment-resistant depression
  • Cognitive Behavioral Therapy (CBT)
  • Interpersonal Therapy (IPT)
  • Behavioral Activation therapy
  • Lifestyle interventions: exercise, sleep hygiene, nutrition

When to Seek Help

Seek help if depressive symptoms have persisted for two weeks or more, are interfering with work or relationships, or if you are having any thoughts of self-harm or suicide. Depression is highly treatable — early intervention leads to better outcomes.

You don't have to navigate this alone.

Zoe Karpee, PMHNP-BC, offers compassionate, evidence-based psychiatric care in East Flat Rock, NC and across North Carolina via telehealth. New patients welcome.

Telehealth available statewide in North Carolina · In-person in East Flat Rock (Henderson County)

Medical Disclaimer: This page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for diagnosis and treatment of any mental health condition.