Man sitting alone looking hopeful representing substance use recovery

DSM-5 · F10–F19

Substance Use Disorders

Substance use disorders involve compulsive use of substances despite harmful consequences, driven by changes in brain chemistry.

DSM-5 Clinical Definition

"A cluster of cognitive, behavioral, and physiological symptoms indicating that the individual continues using the substance despite significant substance-related problems."

Substance Use Disorders (SUDs) involve a pattern of using alcohol, prescription medications, or illicit drugs that causes significant impairment or distress. They are characterized by loss of control over use, continued use despite negative consequences, and physiological changes including tolerance and withdrawal. SUDs affect approximately 20 million Americans annually and are highly co-occurring with other psychiatric conditions including depression, anxiety, PTSD, and ADHD.

Ready to get help?

Board-certified PMHNP-BC Zoe Karpee provides evidence-based psychiatric care in East Flat Rock, NC and statewide via telehealth.

Book an Appointment (828) 316-5548

New patients welcome · Telehealth statewide

Signs & Symptoms

Symptoms vary by individual. A clinical evaluation is required for diagnosis.

Loss of control

Using more of a substance than intended, or for longer than planned, despite attempts to cut back.

Craving

Strong urge or compulsion to use the substance that is difficult to resist.

Tolerance

Needing increasingly larger amounts of the substance to achieve the same effect.

Withdrawal

Physical or psychological symptoms when the substance is reduced or stopped (varies by substance).

Neglect of responsibilities

Failing to fulfill obligations at work, school, or home due to substance use.

Continued use despite harm

Persisting in use despite awareness of physical, psychological, social, or legal consequences.

Evidence-Based Treatment

At Wellness Behavioral Health and Healing PLLC, treatment plans are individualized and grounded in the latest psychiatric evidence. Options may include:

  • Medication-Assisted Treatment (MAT): buprenorphine/naloxone for opioid use disorder
  • Naltrexone for alcohol and opioid use disorders
  • Acamprosate and disulfiram for alcohol use disorder
  • Motivational Interviewing (MI)
  • Cognitive Behavioral Therapy (CBT) for relapse prevention
  • Dual diagnosis treatment for co-occurring psychiatric conditions

When to Seek Help

Seek help when substance use is causing problems in any area of life — health, relationships, work, finances, or legal issues. Addiction is a medical condition, not a moral failing. Medication-assisted treatment is highly effective and can be started quickly.

You don't have to navigate this alone.

Zoe Karpee, PMHNP-BC, offers compassionate, evidence-based psychiatric care in East Flat Rock, NC and across North Carolina via telehealth. New patients welcome.

Telehealth available statewide in North Carolina · In-person in East Flat Rock (Henderson County)

Medical Disclaimer: This page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for diagnosis and treatment of any mental health condition.